Enzymatic and nonenzymatic formation of reactive oxygen species from 6-anilino-5,8-quinolinequinone.

@article{Hasegawa2004EnzymaticAN,
  title={Enzymatic and nonenzymatic formation of reactive oxygen species from 6-anilino-5,8-quinolinequinone.},
  author={Toyoshi Hasegawa and Atsushi Bando and Koichiro Tsuchiya and Shinji Abe and Masumi Okamoto and Kazuyoshi Kirima and Satoru Ueno and Masanori Yoshizumi and Hitoshi Houchi and Toshiaki Tamaki},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1670 1},
  pages={19-27}
}
The nonenzymatic and enzymatic formation of reactive oxygen species (ROS) from LY83583 (6-anilino-5,8-quinolinequinone) was investigated by electron paramagnetic resonance (EPR) spectroscopy. In the presence of thiol compounds such as glutathione and L-cysteine, LY83583 underwent a one-electron reduction due to low redox potential (-0.3+/-0.01 V vs. SCE), followed by formation of LY83583 semiquinone anion radical. This species was characterized by EPR spectroscopy under an argon atmosphere at… CONTINUE READING
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