Enzymatic and Chemoenzymatic Syntheses of Disialyl Glycans and Their Necrotizing Enterocolitis Preventing Effects.

@article{Yu2017EnzymaticAC,
  title={Enzymatic and Chemoenzymatic Syntheses of Disialyl Glycans and Their Necrotizing Enterocolitis Preventing Effects.},
  author={Hai Yu and Xuebin Yan and Chloe Autran and Yanhong Li and Sabrina Etzold and Joanna Latasiewicz and Bianca M Robertson and Jiaming Li and Lars Bode and Xi Chen},
  journal={The Journal of organic chemistry},
  year={2017},
  volume={82 24},
  pages={13152-13160}
}
Necrotizing enterocolitis (NEC) is one of the most common and devastating intestinal disorders in preterm infants. Therapies to meet the clinical needs for this special and highly vulnerable population are extremely limited. A specific human milk oligosaccharide (HMO), disialyllacto-N-tetraose (DSLNT), was shown to contribute to the beneficial effects of… CONTINUE READING