Enzymatic activity is required for the in vivo functions of CARM1.

  title={Enzymatic activity is required for the in vivo functions of CARM1.},
  author={Daehoon Kim and Jaeho Lee and Donghang Cheng and Jie Li and Carla Carter and Ellen R Richie and Mark T Bedford},
  journal={The Journal of biological chemistry},
  volume={285 2},
CARM1 is one of nine protein arginine methyltransferases that methylate arginine residues in proteins. CARM1 is recruited by many different transcription factors as a positive regulator. Gene targeting of CARM1 in mice has been performed, and knock-out mice, which are smaller than their wild-type littermates, die just after birth. It has been proposed that CARM1 has functions that are independent of its enzymatic activity. Indeed, CARM1 is found to interact with a number of proteins and may… CONTINUE READING


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CARM1 Knock-in Phenocopies the Knock-out 1152 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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