Enzymatic Oxidation of Cholesterol: Properties and Functional Effects of Cholestenone in Cell Membranes

@inproceedings{Neuvonen2014EnzymaticOO,
  title={Enzymatic Oxidation of Cholesterol: Properties and Functional Effects of Cholestenone in Cell Membranes},
  author={Maarit Neuvonen and Moutusi Manna and Sini Mokkila and Matti Javanainen and Tomasz R{\'o}g and Zheng Liu and Robert Bittman and Ilpo Vattulainen and Elina Ikonen},
  booktitle={PloS one},
  year={2014}
}
Bacterial cholesterol oxidase is commonly used as an experimental tool to reduce cellular cholesterol content. That the treatment also generates the poorly degradable metabolite 4-cholesten-3-one (cholestenone) has received less attention. Here, we investigated the membrane partitioning of cholestenone using simulations and cell biological experiments and assessed the functional effects of cholestenone in human cells. Atomistic simulations predicted that cholestenone reduces membrane order… CONTINUE READING

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