Corpus ID: 40194433

Enzymatic Inactivation of W-Nìtroso Compounds in Murine Blood Plasma1

  title={Enzymatic Inactivation of W-N{\~A}¬troso Compounds in Murine Blood Plasma1},
  author={R. Brundrett and S. L. Aukerman},
Murine blood plasma rapidly inactivates nitrosamides and nitrosocarbamates but not nitrosoureas. The mechanism of this inactivation in murine blood plasma has been investigated. The vast majority of activity (>97%) was inhibited by serine hydroxylase inhibitors. Also, 92% of the activity was inhibited by bis(pnitrophenyl)phosphate, a selective inhibitor of carboxy(esterases. Decomposition products formed after blood plasma action on Nethyl-N-nitrosoacetamide or W-methyl-A/-nitrosoethylcarbamate… Expand

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