Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds

  title={Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds},
  author={Julius Axelrod},
  pages={343 - 343}
  • J. Axelrod
  • Published 1961
  • Chemistry, Medicine
  • Science
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine. 
Psychotomimetic N-Methylated Tryptamines: Formation in Brain in vivo and in vitro
An enzyme that converts tryptamine and N-methyl-tryptamine to N- methyl-and dimethyltryptamine was found to be present in rat and human brain. Expand
Methyltetrahydrofolic Acid Mediates N- and O-Methylation of Biogenic Amines
With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain. Expand
Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine.
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A new metabolic pathway for N,N-dimethyltryptamine
N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is presentExpand
Indole(ethyl)amine N-methyltransferase in human brain.
Preliminary evidence gathered in laboratories from rats infused intraventricularly with bufotenin has suggested that this substance is at least as potent as its powerfully hallucinogenic 5-methoxy congener, and may not easily cross the blood-brain barrier. Expand
Sympatholytic drugs and some enzymes involved in the metabolism of catecholamines
Summary The influence of phenoxybenzamine, bretylium and guanethidine upon serum and tissue MAO and dopa decar☐ylase in vitro and in vivo was studied. Phenoxybenzamine increases the degree ofExpand
An endogenous inhibitor of indoleamine-N-methyltransferase in cerebrospinal fluid.
Abstract Human cerebrospinal fluid (CSF) has been found to contain a potent inhibitor of rabbit lung indoleamine-N-methyltransferase. Inhibition is non-competitive with respect to both the methylExpand
N, N-dimethyltryptamine: an endogenous hallucinogen.
DMT fulfills the criteria for consideration as a neurotransmitter or a neuromodulator per se and is shown to lead to the production of cyclic adenosine monophosphate, a secondary receptor messenger. Expand
When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor
This work presents a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Expand
An endogenous inhibitor of N-methyltransferase activity and opiate receptor binding in rabbit tissue
A peptide extracted from newborn rabbit brain, lung and liver has the ability to inhibit adult rabbit lung N-methyltransferase activity in vitro and can also bind to opiate receptor in rat brain homogenate. Expand


A report on the assay, purification, properties, and distribution of this enzyme is in preparation