Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds

@article{Axelrod1961EnzymaticFO,
  title={Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds},
  author={Julius Axelrod},
  journal={Science},
  year={1961},
  volume={134},
  pages={343 - 343}
}
  • J. Axelrod
  • Published 1961
  • Chemistry, Medicine
  • Science
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine. 
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References

A report on the assay, purification, properties, and distribution of this enzyme is in preparation