Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon


The isolated homeobox gene Enx (Hox11L1) is expressed in enteric neurons innervating distal ileum, and proximal and distal colon. Enx-deficient mice develop megacolon with massive distension of the proximal colon. The number of myenteric ganglia, total neurons per ganglion, and NADPH diaphorase presumptive inhibitory neurons per ganglion are increased in… (More)
DOI: 10.1038/nm0697-646


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