Environmentally persistent alkylphenolic compounds are estrogenic.

  title={Environmentally persistent alkylphenolic compounds are estrogenic.},
  author={Robert J. White and Susan Jobling and Siobhan Hoare and John P. Sumpter and Malcolm G. Parker},
  volume={135 1},
We show that a number of alkylphenolic compounds, used in a variety of commercial products and found in river water, are estrogenic in fish, birds, and mammals. 4-Octylphenol (OP), 4-nonylphenol, 4-nonylphenoxycarboxylic acid, and 4-nonylphenoldiethoxylate were each capable of stimulating vitellogenin gene expression in trout hepatocytes, gene transcription in transfected cells, and the growth of breast cancer cell lines. The most potent of the chemicals is OP, which was able to stimulate these… CONTINUE READING
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