Environmentally-induced modification of the benzodiazepine/GABA receptor coupled chloride ionophore

@article{Trulls1987EnvironmentallyinducedMO,
  title={Environmentally-induced modification of the benzodiazepine/GABA receptor coupled chloride ionophore},
  author={Ram{\'o}n Trull{\'a}s and H. Havoundjian and Nadav Zamir and Steven M Paul and Philip Skolnick},
  journal={Psychopharmacology},
  year={1987},
  volume={91},
  pages={384-390}
}
The benzodiazepine/GABA receptor coupled chloride ionophore was examined in brain membranes of rats maintained in either a conventional animal facility or a “protected” (low-stress) environment. Following a 10 min ambient temperature swim, animals maintained in both environments had qualitatively similar increases in the number (B max) of [35S]t-butylbicyclophosphorothionate (TBPS) binding sites, the apparent affinity of this radioligand, and the efficacy and potency of Cl− to enhance [3H… CONTINUE READING

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