Environmentally induced epigenetic transgenerational inheritance of disease susceptibility.

  title={Environmentally induced epigenetic transgenerational inheritance of disease susceptibility.},
  author={Eric E Nilsson and Michael K. Skinner},
  journal={Translational research : the journal of laboratory and clinical medicine},
  volume={165 1},
Environmental insults, such as exposure to toxicants or nutritional abnormalities, can lead to epigenetic changes that are in turn related to increased susceptibility to disease. The focus of this review is on the transgenerational inheritance of such epigenetic abnormalities (epimutations), and how it is that these inherited epigenetic abnormalities can lead to increased disease susceptibility, even in the absence of continued environmental insult. Observations of environmental toxicant… CONTINUE READING
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