Environmentally Responsive Ophthalmic Gel Formulation of Carteolol Hydrochloride

@article{ElKamel2006EnvironmentallyRO,
  title={Environmentally Responsive Ophthalmic Gel Formulation of Carteolol Hydrochloride},
  author={Amal Hassan El-Kamel and Heba Al-Dosari and Fahad Ibrahim Al-Jenoobi},
  journal={Drug Delivery},
  year={2006},
  volume={13},
  pages={55 - 59}
}
Environmentally responsive gel formulation for ocular controlled delivery of carteolol hydrochloride (HCl) was developed in an attempt to improve ocular bioavailability and hence decrease its systemic absorption and side effects. The viscosity and the ability of the prepared formulations to deliver carteolol HCl in vitro and in vivo were monitored and compared with an aqueous commercial solution. The effect of polymer concentration and drug concentration on the in vitro release of carteolol HCl… 

FORMULATION DEVELOPMENT AND EVALUATION OF pH TRIGGERED IN SITU OPHTHALMIC GEL OF EPINASTINE HYDROCHLORIDE

The study revealed that the in situ system of epinastine hydrochloride sustained the effect of drug to 12 hours and the formulations F3 and F7 extended the release of drug upto 12 hours as compare to marketed product (EPINA eye drops) which released 99.22% release within 6hrs.

FORMULATION DEVELOPMENT AND EVALUATION OF ION SENSITIVE IN SITU OPHTHALMIC GEL OF OLOPATADINE HYDROCHLORIDE

The poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in situ forming ophthalmic drug delivery system prepared from polymer that

DEVELOPMENT OF POLOXAMER BASED THERMOSENSITIVE IN SITU OCULAR GEL OF BETAXOLOL HYDROCHLORIDE

Objective: This work was conducted to develop and evaluate Poloxamer 407-HPMC K50M based in situ gelling formulation of Betaxolol Hydrochloride (0.25%w/v) for enhancing its ocular bioavailability and

Novel Polymeric in Situ Gels for Ophthalmic Drug Delivery System

In situ gelling system is a convenient, ease to administer, improve the bioavailability, better patient compliance, and development of hydrogel based drug delivery systems while highlighting the applications ofHydrogel in pharmaceutical field.

Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system

In vivo results in rabbits showed that OFX-loaded microspheres in situ gel formula improved the relative bioavailability by 11.7-fold compared with the commercially available OFX eyedrops, which is thought to avoid frequent instillations, which improves patient tolerability and compliance.

Formulation development of smart gel periodontal drug delivery system for local delivery of chemotherapeutic agents with application of experimental design

Smart gel periodontal drug delivery systems (SGPDDS) containing gellan gum and lutrol F127 exhibited superior physical characteristics and the Korsemeyer-Peppas model was the best fit model for drug release.

Fabrication, Characterization and Evaluation of In Situ Gel for the Treatment of Conjunctivitis

Developed in situ gel formulation of Ofloxacin was effective in terms of treatment of conjunctivitis and improved ability to sustain the drug compared to other formulations by in vitro release studies.

In situ gelling systems of ofloxacin: Comparative performance of in vivo precorneal drainage and pharmacokinetic study

In situ gel‐forming ability of the developed systems significantly controls precorneal drainage as studied by gamma scintigraphy, and increased residence time in the eye would help to increase the ocular bioavailability.

NOVEL INSITU POLYMERIC DRUG DELIVERY SYSTEM: A REVIEW

Sustained and prolonged release of the drug, good stability and biocompatibility characteristics make the in situ gel dosage forms very reliable and from a manufacturing point of view, the production of such devices is less complex and thus lowers the investment and manufacturing.

References

SHOWING 1-10 OF 19 REFERENCES

Rheological evaluation of Gelrite in situ gels for ophthalmic use.

Controlled release of vancomycin from poloxamer 407 gels.

Topical ocular drug delivery: recent developments and future challenges.

The focus of this review is on recent developments in topical ocular drug delivery systems relative to their success in overcoming the constraints imposed by the eye and to the improvements that have yet to be made.

Different Effects of Absorption Promoters on Corneal and Conjunctival Penetration of Ophthalmic Beta-Blockers

Investigation of the improvement in corneal penetration of ophthalmic beta-blockers of various lipophilicities afforded by absorption promoters found a selective use of absorption promoter can improve the extent and pathway of drug ocular absorption.

Ocular Carteolol

SummaryAbstractOcular carteolol (Mikelan®, Teoptic®, Ocupress®) is a nonselective β-adrenoceptor antagonist with intrinsic sympathomimetic activity (ISA). Ocular carteolol effectively reduces

Theory of diffusion in gels.