Environmentally Relevant Level of Aflatoxin B1 Dysregulates Human Dendritic Cells Through Signaling on Key Toll-Like Receptors.

@article{Mohammadi2014EnvironmentallyRL,
  title={Environmentally Relevant Level of Aflatoxin B1 Dysregulates Human Dendritic Cells Through Signaling on Key Toll-Like Receptors.},
  author={Azam Mohammadi and Jalil Mehrzad and Mahmoud Mahmoudi and Marion E. Schneider},
  journal={International journal of toxicology},
  year={2014},
  volume={33 3},
  pages={175-186}
}
Aflatoxins (AFs) are highly hazardous fungal biometabolites usually present in feeds and foods. Aflatoxin B1 (AFB1) is the most toxic and a known carcinogen. Toll-like receptors (TLRs), highly expressed by myeloid dendritic cells (DC), are key innate immune-surveillance molecules. Toll-like receptors not only sense pathogen-associated molecular patterns but also contribute to infections and cancer. To assess AFB1-TLR interactions on human myeloid DC, pure CD11c+ DC were generated from monocytes… CONTINUE READING