Environmental variables differentially affect ethanol-stimulated activity in selectively bred mouse lines

@article{Crabbe1988EnvironmentalVD,
  title={Environmental variables differentially affect ethanol-stimulated activity in selectively bred mouse lines},
  author={J Christopher F Crabbe and Catherine M. Deutsch and Brenda R. Tam and Emmett R. Young},
  journal={Psychopharmacology},
  year={1988},
  volume={95},
  pages={103-108}
}
Low doses of ethanol (EtOH) stimulate activity in an open field in many strains of laboratory mice. We are selectively breeding two lines of mice to exhibit a large (FAST) response on this test, and two other lines to exhibit a small (SLOW) response (Crabbe et al. 1987). The lines initially diverged in response to EtOH, but despite continued selection pressure, the difference between each pair of FAST and SLOW lines has not increased over generations as much as expected. Our practice has been… CONTINUE READING

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