Environmental triggers of autoimmunity in anti-synthetase syndrome: the lungs under the spot light.

@article{KawanoDourado2013EnvironmentalTO,
  title={Environmental triggers of autoimmunity in anti-synthetase syndrome: the lungs under the spot light.},
  author={Leticia Kawano-Dourado and Andr{\'e} N. Costa and Carlos R.R. Carvalho and Ronaldo Adib Kairalla},
  journal={Clinical and experimental rheumatology},
  year={2013},
  volume={31 6},
  pages={950-3}
}
The prevalence of interstitial lung involvement in anti-synthetase syndrome (anti-SS) may be as high as 70% and is a major contributor to morbidity and mortality. Histidyl-tRNA synthetase (Jo-1) is the most common autoantigenic target among the aminoacyl-tRNA synthetases. We report two well documented anti-SS cases where it was observed significant exposure to a known inhaled offending antigen, development of a lymphocytic interstitial lung disease (ILD) and negative auto-antibodies… CONTINUE READING

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