Environmental triggers and determinants of type 1 diabetes.

  title={Environmental triggers and determinants of type 1 diabetes.},
  author={Mikael Knip and Riitta K. Veijola and Suvi Mirjami Virtanen and Heikki Hy{\"o}ty and Outi Vaarala and Hans K. Akerblom},
  volume={54 Suppl 2},
Type 1 diabetes is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta-cells in the pancreatic islets in genetically susceptible subjects. A series of evidence supports a critical role of exogenous factors in the development of type 1 diabetes, such as 1) the fact that <10% of individuals with HLA-conferred diabetes susceptibility do progress to clinical disease, 2) a pairwise concordance of type 1 diabetes… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 21 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 192 extracted citations

Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes

The Journal of experimental medicine • 2013
View 4 Excerpts
Highly Influenced

Autoimmunity and the pathogenesis of type 1 diabetes.

Critical reviews in clinical laboratory sciences • 2010
View 7 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 98 references

[Environmental causes of type 1 diabetes].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke • 2007

Screening of organ donors for anti-islet antibodies and characterization of pancreatic histology in an antibody-positive subject

R Gianini, F Dotta, +5 authors GS Eisenbarth
Abstract book, Immunology of Diabetes Society Meeting, • 2004

Similar Papers

Loading similar papers…