Environmental stresses can alleviate the average deleterious effect of mutations

@article{Kishony2003EnvironmentalSC,
  title={Environmental stresses can alleviate the average deleterious effect of mutations},
  author={Roy Kishony and Stanislas Leibler},
  journal={Journal of Biology},
  year={2003},
  volume={2},
  pages={14 - 14}
}
BACKGROUND Fundamental questions in evolutionary genetics, including the possible advantage of sexual reproduction, depend critically on the effects of deleterious mutations on fitness. Limited existing experimental evidence suggests that, on average, such effects tend to be aggravated under environmental stresses, consistent with the perception that stress diminishes the organism's ability to tolerate deleterious mutations. Here, we ask whether there are also stresses with the opposite… CONTINUE READING
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