Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat.

@article{Meddings2000EnvironmentalSG,
  title={Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat.},
  author={Jon B. Meddings and Mark Gordon Swain},
  journal={Gastroenterology},
  year={2000},
  volume={119 4},
  pages={1019-28}
}
BACKGROUND & AIMS Abnormal presentation of luminal constituents to the mucosal immune system, caused by dysfunction of the intestinal epithelial barrier, is a candidate theory for the cause of Crohn's disease. Increased epithelial permeability is found in subgroups of patients at high risk for the development of Crohn's disease and has been found to precede disease recurrence. Clinical observations have suggested that disease recurrence can follow times of increased psychological stress… CONTINUE READING
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