Environmental sources of scrapie prions.

  title={Environmental sources of scrapie prions.},
  author={Ben Charles Maddison and Claire A. Baker and Linda Ann Terry and Susan Jane Bellworthy and Leigh T Thorne and Helen C Rees and Kevin Christopher Gough},
  journal={Journal of virology},
  volume={84 21},
Ovine scrapie and cervine chronic wasting disease show considerable horizontal transmission. Here we report that a scrapie-affected sheep farm has a widespread environmental contamination with prions. Prions were amplified by protein-misfolding cyclic amplification (sPMCA) from seven of nine environmental swab samples taken, including those from metal, plastic, and wooden surfaces. Sheep had been removed from the areas from which the swabs were taken up to 20 days prior to sampling, indicating… CONTINUE READING
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