Environmental risk factors in systemic sclerosis

@article{Dospinescu2013EnvironmentalRF,
  title={Environmental risk factors in systemic sclerosis},
  author={Paula Dospinescu and Gareth T. Jones and Neil Basu},
  journal={Current Opinion in Rheumatology},
  year={2013},
  volume={25},
  pages={179–183}
}
Purpose of reviewEnvironmental risk factors have been implicated in the pathogenesis of systemic sclerosis (SSc). Recent evidence further supports this relationship and constitutes the focus of this review article. Recent findingsExposure to silica through various occupations remains one of the main environmental risk factors for SSc. Emerging evidence has also implicated organic solvents in the development of this difficult-to-manage condition. The individual role of these toxins is, however… 

An overview of environmental risk factors in systemic sclerosis

TLDR
The following review analyzes the most recent literature to examine the relationship between environmental exposures and SSc and concludes that the disease is probably caused by both endogenous and exogenous factors.

Occupational and environmental scleroderma. Systematic review and meta-analysis

TLDR
A meta-analysis of all studies published on SSc associated with occupational and environmental exposure from 1960 to 2014 found silica and solvents were the two most likely substances related to the pathogenesis of SSc.

Is exposure to environmental factors associated with a characteristic clinical and laboratory profile in systemic sclerosis? A retrospective analysis

TLDR
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Systemic sclerosis and silica exposure: a rare association in a large Brazilian cohort

TLDR
To conclude, ES was rare in this large SSc cohort, although associated with a bad prognosis, and Multivariate analysis did not confirm that silicosis is an independent risk factor for SSc.

Pathophysiology and recent findings of primary biliary cirrhosis complicated by systemic sclerosis

TLDR
Because PBC is often complicated by rheumatic disease, hepatologists should keep the possibility of systemic disorder in mind when examining PBC patients, and particular attention should be paid to the management of gastroesophageal varices.

The spectrum of orofacial manifestations in systemic sclerosis: a challenging management.

TLDR
The identification of specific radiological and clinical signs at the early stage will improve the management of systemic sclerosis patients and suggest clues for the oral management that remains challenging.

Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells

TLDR
It is suggested that environmental DEP could trigger the development of SSc acting on genetically hyperreactive cell systems, in which the pathogenetic role of environment has been highlighted.

Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review

TLDR
A case is described that can support previous observations, strengthening this association with previous silicone implants and/or breast cancer, and Clinicians should be aware of this new clinical entity, given the widespread use of silicone implants.

Nonendocrine mechanisms of sex bias in rheumatic diseases

  • N. Lambert
  • Medicine, Biology
    Nature Reviews Rheumatology
  • 2019
TLDR
This Review outlines several genetic and epigenetic mechanisms that could explain sex bias in rheumatic diseases, including X chromosome inactivation, sex chromosome aneuploidy and microchimerism, considering evidence from clinical and experimental studies.

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