Environmental risk factors for multiple sclerosis. Part I: The role of infection

  title={Environmental risk factors for multiple sclerosis. Part I: The role of infection},
  author={A. Ascherio and K. Munger},
  journal={Annals of Neurology},
  • A. Ascherio, K. Munger
  • Published 2007
  • Medicine
  • Annals of Neurology
  • Although genetic susceptibility explains the clustering of multiple sclerosis (MS) cases within families and the sharp decline in risk with increasing genetic distance, it cannot fully explain the geographic variations in MS frequency and the changes in risk that occur with migration. Epidemiological data provide some support for the “hygiene hypothesis,” but with the additional proviso for a key role of Epstein–Barr virus (EBV) in determining MS risk. We show that whereas EBV stands out as the… CONTINUE READING
    908 Citations

    Topics from this paper

    Paper Mentions

    Interventional Clinical Trial
    Purpose of study is to determine safety and efficacy of use of autologous Adipose-Derived cellular Stromal Vascular Fraction (AD-cSVF) suspended in Normal Saline and delivered via… Expand
    ConditionsAutoimmune, Multiple Sclerosis
    InterventionDevice, Procedure
    Environmental factors in multiple sclerosis
    • A. Ascherio
    • Medicine
    • Expert review of neurotherapeutics
    • 2013
    • 155
    The Role of Environment and Lifestyle in Determining the Risk of Multiple Sclerosis.
    • 25
    Epidemiology of multiple sclerosis: from risk factors to prevention.
    • 162
    • PDF
    The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis
    • 138
    • PDF
    Environmental risk factors in multiple sclerosis
    • K. Lauer
    • Medicine
    • Expert review of neurotherapeutics
    • 2010
    • 22
    Is the hygiene hypothesis relevant for the risk of multiple sclerosis?
    • 12


    Epidemiologic evidence for multiple sclerosis as an infection.
    • J. Kurtzke
    • Biology, Medicine
    • Clinical Microbiology Reviews
    • 1993
    • 476
    • Highly Influential
    • PDF
    Role of viruses in etiology and pathogenesis of multiple sclerosis
    • 53
    Herpesvirus and multiple sclerosis.
    • A. Simmons
    • Medicine
    • Herpes : the journal of the IHMF
    • 2001
    • 106
    Does epstein-barr virus cause multiple sclerosis?
    • S. Cook
    • Medicine
    • Reviews in neurological diseases
    • 2004
    • 15