Environmental risk factors for inhibitor development in children with haemophilia A: a case-control study.

@article{Santagostino2005EnvironmentalRF,
  title={Environmental risk factors for inhibitor development in children with haemophilia A: a case-control study.},
  author={Elena Santagostino and Maria Elisa Mancuso and Angiola Rocino and Giacomo Mancuso and Maria Gabriella Mazzucconi and Annarita Tagliaferri and Maria G Messina and Pier Mannuccio Mannucci},
  journal={British journal of haematology},
  year={2005},
  volume={130 3},
  pages={
          422-7
        }
}
This case-control study investigated the interactions between genetic and environmental factors and inhibitor development in 108 children with haemophilia A exclusively treated with recombinant factor VIII (FVIII). Sixty patients with inhibitors were compared with 48 inhibitor-free controls. Family history of inhibitors and null mutations in the FVIII gene were more prevalent in cases than in controls (20% vs. 2%, P = 0.001 and 83% vs. 64%, P = 0.04, respectively). On the other hand, there was… CONTINUE READING

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