Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse?

@article{Meaney2002EnvironmentalRO,
  title={Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse?},
  author={Michael J. Meaney and Wayne G. Brake and Alain P Gratton},
  journal={Psychoneuroendocrinology},
  year={2002},
  volume={27 1-2},
  pages={127-38}
}
Repeated periods of maternal separation in the early life of rats decreased dopamine transporter expression and significantly increased dopamine responses to stress, and behavioral responses to either stress or cocaine. As adults, maternal separation animals showed increased sensitivity to the effects of cocaine on locomotor activity and greater sensitivity to stress-induced sensitization to the effects of amphetamine on locomotor activity. These findings raise the possibility that in addition… CONTINUE READING
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