Environmental pollution and risk of psychotic disorders: A review of the science to date

  title={Environmental pollution and risk of psychotic disorders: A review of the science to date},
  author={Luigi Attademo and Francesco Bernardini and Raffaele Garinella and Michael T. Compton},
  journal={Schizophrenia Research},
Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark
Results show that air pollution is significantly associated with increased risk of psychiatric disorders, and it is hypothesized that pollutants affect the human brain via neuroinflammatory pathways that have also been shown to cause depression-like phenotypes in animal studies.
Air Pollution as Risk Factor for Mental Disorders: In Search for a Possible Link with Alzheimer's Disease and Schizophrenia.
Urban exposure to environmental toxins and pollution is currently described as a reliable risk factor for schizophrenia and other psychoses, and it has been demonstrated more and more how exposure to air pollutants is associated with increased risk of dementia.
Gene–environment interplay in the etiology of psychosis
To reach a more complete explanation of psychosis that can inform preventive strategies, future research should focus on longitudinal assessments of multiple environmental exposures within large, genotyped cohorts beginning early in life.
Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms
Available evidence suggests that exposure to harmful air quality may be associated with suicidality, and there are significant public health implications which are amplified in regions and countries with greater levels of air pollution and aeroallergens.
Prenatal Maternal Stress and the Cascade of Risk to Schizophrenia Spectrum Disorders in Offspring
Disruptions in fetal development (via genetic and environmental pathways) have been consistently associated with risk for schizophrenia in a variety of studies. Although multiple obstetric
Effect of Environmental Pollutants on Neurological Disorders
It has been seen that environmental pollutants triggers the oxidative stress and cause neurotoxicity and inflammation of the neuron cells which in longer term causes different neurodegenerative diseases.
Environmental Determinants of Urban Mental Health: a Literature Review
  • IM Sineva, AA Khafizova, I. Permyakov
  • Medicine, Psychology
  • 2021
The findings indicate the importance of further research on the influence of urban environment on mental health, the results of which can be implemented in various hygiene practices and urban planning programs.
Association between air pollution exposure and mental health service use among individuals with first presentations of psychotic and mood disorders: retrospective cohort study
Residential air pollution exposure is associated with increased mental health service use among people recently diagnosed with psychotic and mood disorders and interventions to reduceAir pollution exposure could improve mental health prognoses and reduce healthcare costs.
Prevention of Deficit in Neuropsychiatric Disorders through Monitoring of Arsenic and Its Derivatives as Well as Through Bioinformatics and Cheminformatics
The aim is to better understand the molecular mechanisms of arsenic toxicity in the brain and to elucidate possible ways to prevent arsenic neurotoxicity, by reviewing significant experimental, bioinformatics, and cheminformatics studies.


The Role of Lead and Cadmium in Psychiatry
  • O. Orisakwe
  • Psychology, Medicine
    North American journal of medical sciences
  • 2014
Evidence-based information suggests that lead and cadmium may be involved in psychiatry, and it is worthwhile for toxicologists and scientists in Sub-Sahara Africa to investigate if lead and Cadmium can become additional biomarkers in the diagnosis of psychiatric disorders.
Toxic exposures and psychiatric disease — lessons from the epidemiology of cancer
  • P. Landrigan
  • Medicine
    Acta psychiatrica Scandinavica. Supplementum
  • 1983
Toxic chemicals such as lead, methyl mercury, organic solvents, manganese, kepone, and the organophosphates are recognized to cause psychiatric disease. Whether such associations are exceptional, or
Air Pollution and Neuropsychological Development: A Review of the Latest Evidence.
The latest epidemiological studies support the hypothesis that pre- or postnatal exposure to ambient pollution, particularly polycyclic aromatic hydrocarbons, PM2.5, and nitrogen oxides has a negative impact on the neuropsychological development of children.
The Adverse Effects of Air Pollution on the Nervous System
Emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology.
From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia
This review of molecular dysregulation in schizophrenia will focus on epigenetic modifications as a key mechanism through which environmental factors interact with individual's genetic constitution to affect risk of psychotic conditions throughout life.
Schizophrenia and urbanicity: a major environmental influence--conditional on genetic risk.
The available evidence suggests that causation (urban environment causes psychosis) is more important than selection (high-risk individuals move into urban areas) and that the effect of the environmental factors in the urban environment is conditional on genetic risk (i.e., there may be gene-environment interaction).
Urban birth and risk of schizophrenia: a worrying example of epidemiology where the data are stronger than the hypotheses
The psychiatric research community should have a sense of urgency in exploring the mechanisms linking urban birth and risk of schizophrenia, and the attributable fraction of schizophrenia associated with urban birth may increase.
Urbanicity, social adversity and psychosis
It is unlikely that social drift alone can fully account for geographical variation in incidence of schizophrenia, and evidence suggests the impact of adverse social contexts – indexed by area‐level exposures such as population density, social fragmentation and deprivation – on risk of psychosis is explained.