Environmental pollutants and hydroxysteroid dehydrogenases.

  title={Environmental pollutants and hydroxysteroid dehydrogenases.},
  author={Leping Ye and Jingjing Guo and Ren-Shan Ge},
  journal={Vitamins and hormones},
Hydroxysteroid dehydrogenases (HSD) are a group of steroidogenic enzymes that are involved in the steroid biosynthesis and metabolism. Four classes of HSDs, namely, 3β-, 11β-, 17β-, and 20α-HSDs, are discussed. 3β-HSDs catalyze the conversion of pregnenolone, 17α-hydroxypregnenolone, and dehydroepiandrosterone to progesterone, 17α-hydroxyprogesterone, and androstenedione, respectively. 11β-HSDs catalyze the interconversion between active cortisol and inactive cortisone. 17β-HSDs catalyze the… CONTINUE READING
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