Environmental pollutants, diet, physical activity, body size, and breast cancer

@article{Brody2007EnvironmentalPD,
  title={Environmental pollutants, diet, physical activity, body size, and breast cancer},
  author={Julia Green Brody and Ruthann A. Rudel and Karin B. Michels and Kirsten B. Moysich and Leslie Bernstein and Kathleen R Attfield and Sharon Gray},
  journal={Cancer},
  year={2007},
  volume={109}
}
Breast cancer is the most common invasive cancer in women worldwide and the leading cause of death in US women in mid‐life. Treatment has adverse effects, adding to the importance of finding modifiable risk factors. At the invitation of Susan G. Komen for the Cure, we reviewed studies of breast cancer and environmental pollutants, diet (assessed prospectively), body size, and physical activity, and animal studies that identify chemicals as potential mammary carcinogens. Databases developed in… 
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References

SHOWING 1-10 OF 44 REFERENCES
Breast cancer and environmental risk factors: epidemiological and experimental findings.
TLDR
Research on etiology of breast cancer should measure environmental exposures and take into account the time of life at which these occur, as well as complex interactions between exogenous and endogenous carcinogenic agents need further focus.
Environmental pollutants and breast cancer.
TLDR
Evidence to date generally supports an association between breast cancer and polycyclic aromatic hydrocarbons and polychlorinated biphenyls in conjunction with certain genetic polymorphisms involved in carcinogen activation and steroid hormone metabolism.
Chemicals causing mammary gland tumors in animals signal new directions for epidemiology, chemicals testing, and risk assessment for breast cancer prevention
TLDR
This is the most comprehensive list developed of animal mammary gland carcinogens and, along with associated data, is publicly available at URL: www.silentspring.org/sciencereview.
Diet and breast cancer
TLDR
There is no association that is consistent, strong, and statistically significant, with the exception of alcohol intake, overweight, and weight gain, among the prospective epidemiologic studies conducted on diet and breast cancer incidence and gene‐diet interactions.
Alcohol and breast cancer in women: a pooled analysis of cohort studies.
TLDR
Alcohol consumption is associated with a linear increase in breast cancer incidence in women over the range of consumption reported by most women, and reducing alcohol consumption is a potential means to reduce breast cancer risk.
Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts.
  • M. GammonR. Santella V. Vinceguerra
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2002
TLDR
Data indicate that PAH-DNA adduct formation may influence breast cancer development, although the association does not appear to be dose dependent and may have a threshold effect.
Chemically induced mammary gland cancer in the National Toxicology Program's carcinogenesis bioassay.
TLDR
Experimental studies show that chemicals identified to cause mammary gland cancer in rodents are frequently mutagenic chemicals, suggesting that genetic damage is an important mechanism for the induction of this cancer.
Review of anthropometric factors and breast cancer risk
  • C. Friedenreich
  • Medicine, Biology
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2001
TLDR
Sufficient evidence exists to support strategies to avoid weight gain throughout life as a means of reducing postmenopausal breast cancer risk, and recommendations for future research on anthropometric factors and breast cancer are provided.
Occupational cancer among women: where have we been and where are we going?
  • S. ZahmA. Blair
  • Medicine, Economics
    American journal of industrial medicine
  • 2003
TLDR
Occupational cancer researchers need to expand their focus on women, increase activities in developing countries, include newly created industries, use sophisticated exposure assessment methods, and, where appropriate, incorporate molecular epidemiologic techniques to discover new occupational carcinogens and to identify where better control measures are needed.
Community-Initiated Breast Cancer and Environment Studies and the Precautionary Principle
TLDR
Examining three activist-initiated breast cancer and environment studies is augmented by examining how the choice of research questions affects the potential of results to inform action, and the crucial importance of developing and applying new exposure assessment methods.
...
...