Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression

@article{Thiel2010EnvironmentalLC,
  title={Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression},
  author={Kenneth J. Thiel and Nathan S. Pentkowski and Natalie A. Peartree and M. R. Painter and Janet L. Neisewander},
  journal={Neuroscience},
  year={2010},
  volume={171},
  pages={1187-1196}
}
Environmental enrichment (EE) introduced during abstinence from cocaine self-administration is protective in reducing cue-elicited incentive motivation for cocaine in rats. This study examined neural activation associated with this protective effect of EE using Fos protein expression as a marker. Rats were trained to press a lever reinforced by cocaine (0.75 mg/kg/0.1 mL infusion) and light and tone cues across 15 consecutive days during which they were all housed in isolated conditions (IC… CONTINUE READING

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