Environmental influence on L1 retrotransposons in the adult hippocampus.

  title={Environmental influence on L1 retrotransposons in the adult hippocampus.},
  author={Alysson Renato Muotri and Chunmei Zhao and Maria C. N. Marchetto and Fred H. Gage},
  volume={19 10},
It is well established that neuronal circuits can be shaped by experience. Neuronal plasticity can be achieved by synaptic competitive interactions and the addition of new neuronal units in neurogenic regions of the adult brain. Recent data have suggested that neuronal progenitor cells can accommodate somatic LINE-1 (Long Interspersed Nuclear Elements-1 or L1) retrotransposition. Genomic L1 insertions may up- or down-regulate transcriptional control of gene expression. Here, we show that… CONTINUE READING
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