Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm.

@article{Prindull2004EnvironmentalGO,
  title={Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm.},
  author={Gregor Prindull and Dov Zipori},
  journal={Blood},
  year={2004},
  volume={103 8},
  pages={2892-9}
}
Epithelial mesenchymal transitions are a remarkable example of cellular plasticity. These transitions are the hallmark of embryo development, are pivotal in cancer progression, and seem to occur infrequently in adult organisms. The reduced incidence of transitions in the adult could result from restrictive functions of the microenvironment that stabilizes adult cell phenotypes and prevents plastic behavior. Multipotential progenitor cells exhibiting a mesenchymal phenotype have been derived… CONTINUE READING

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