Environmental factors in declining human fertility

@article{Skakkebk2021EnvironmentalFI,
  title={Environmental factors in declining human fertility},
  author={Niels E. Skakkeb{\ae}k and Rune Lindahl-Jacobsen and Hagai Levine and A M Andersson and Niels J{\o}rgensen and Katharina M Main and {\O}jvind Lidegaard and L{\ae}rke Priskorn and Stine Agergaard Holmboe and Elvira V. Br{\"a}uner and Kristian Almstrup and Luiz Renato de França and Ariana Znaor and Andreas Kortenkamp and Roger J. Hart and Anders Juul},
  journal={Nature Reviews Endocrinology},
  year={2021},
  volume={18},
  pages={139 - 157}
}
A severe decline in child births has occurred over the past half century, which will lead to considerable population declines, particularly in industrialized regions. A crucial question is whether this decline can be explained by economic and behavioural factors alone, as suggested by demographic reports, or to what degree biological factors are also involved. Here, we discuss data suggesting that human reproductive health is deteriorating in industrialized regions. Widespread infertility and… 
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References

SHOWING 1-10 OF 289 REFERENCES
Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility.
TLDR
There is an urgent need to prioritize research in reproductive physiology and pathophysiology, particularly in highly industrialized countries facing decreasing populations, because environmental exposures arising from modern lifestyle, rather than genetics, are the most important factors in the observed trends.
Has Human Fertility Declined Over Time?: Why We May Never Know
TLDR
Over the past 5 decades, changes in social factors that affect the rate and fate of unintended pregnancies could substantially bias time trends in fertility.
Declining trends in conception rates in recent birth cohorts of native Danish women: a possible role of deteriorating male reproductive health
TLDR
It is found that younger cohorts had progressively lower TNCR and that in terms of their total fertility rate, the declining T NCR is compensated by an increasing use of ART, which may imply increasing reproductive health problems and lower fertility in the future.
Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union.
TLDR
EDCs may contribute substantially to male reproductive disorders and diseases, with nearly €15 billion annual associated costs in the EU, and public health costs should be considered as the EU contemplates regulatory action on EDCs.
Dizygotic twinning as a measure of human fertility.
TLDR
It is suggested that it could have been due to a depression in the twin ovulation rate in women who stopped taking the oral contraceptive pill, and this makes it possible to use the dizygotic:monozygotic twinning ratio to monitor dIZygotic twinting in populations where true incidence rates cannot be calculated.
Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals
TLDR
This review uses the adverse outcome pathway (AOP) concept to summarize current knowledge about how chemical exposure can affect female reproductive health and proposes ten putative AOPs relevant for female reproductive disorders that can be further elaborated and potentially be included in the AOPwiki.
Adverse trends in male reproductive health: we may have reached a crucial ‘tipping point’
TLDR
The sperm counts of the majority of 20 year old European men are now so low that the authors may be close to the crucial tipping point of 40 mill/mL spermatozoa, which would mean the possibility of more infertile couples and lower fertility rates in the future.
Temporal Trends in Fertility Rates: A Nationwide Registry Based Study from 1901 to 2014
TLDR
This nationwide study shows that women above 30 years of age historically have been able to sustain fertility rates above replacement level, which implies that other factors besides age are strong determinants of fertility in women above30 years ofAge.
Female exposure to endocrine disrupting chemicals and fecundity: a review
TLDR
There is limited evidence to conclude that female exposure to nonpersistent EDCs affect fecundity in humans, and further studies focusing on exposure to mixtures of EDCs are needed.
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