Environmental epigenomics in human health and disease.

@article{Dolinoy2008EnvironmentalEI,
  title={Environmental epigenomics in human health and disease.},
  author={Dana C Dolinoy and Randy L. Jirtle},
  journal={Environmental and molecular mutagenesis},
  year={2008},
  volume={49 1},
  pages={4-8}
}
The epigenome consists of the DNA methylation marks and histone modifications involved in controlling gene expression. It is accurately reproduced during mitosis and can be inherited transgenerationally. The innate plasticity of the epigenome also enables it to be reprogrammed by nutritional, chemical, and physical factors. Imprinted genes and metastable epialleles represent two classes of genes that are particularly susceptible to environmental factors because their regulation is tightly… CONTINUE READING

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