Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus

@article{Torasdotter1998EnvironmentalER,
  title={Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus},
  author={Marita Torasdotter and Madis Metsis and Bengt G. Henriksson and Bengt Winblad and Abdul Kadir H Mohammed},
  journal={Behavioural Brain Research},
  year={1998},
  volume={93},
  pages={83-90}
}
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179 Citations
Highly Influential Citations
7
Background Citations
58
Methods Citations
3

179 Citations

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Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain
TLDR
Findings demonstrate significant alterations in NGF, BDNF, and NT-3 protein levels in several brain regions as a result of an enriched versus an isolated environment and thus provide a possible biochemical basis for behavioral and morphological alterations that have been found to occur with a shifting environmental stimulus.
Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment: implications for molecular plasticity.
Environmental enrichment attenuates cognitive deficits, but does not alter neurotrophin gene expression in the hippocampus following lateral fluid percussion brain injury
Influence of environmental enrichment on steady-state mRNA levels for EAAC1, AMPA1 and NMDA2A receptor subunits in rat hippocampus
Brain neurotrophin levels and mouse behavior : relationship to environmental influences
TLDR
These results demonstrated for the first time that alternate housing had significant impact on behaviour and neurotrophin levels in selected brain regions in mice, which can be partially altered by voluntary physical exercise and suggested that substantial changes induced by intermittent social isolation are different from previous findings caused by sustained social isolation.
Layer and regional effects of environmental enrichment on the pyramidal neuron morphology of the rat
How Does an Enriched Environment Impact Hippocampus Brain Plasticity?
TLDR
The major role of the immune system is demonstrated in modulating EE-induced changes to hippocampal plasticity, which involves a variety of immune cells (including macrophages, microglia, natural killer, B-cells, and T-cells), although the mechanisms are yet to be fully elucidated.
Exposure to enriched environment improves spatial learning performances and enhances cell density but not choline acetyltransferase activity in the hippocampus of ventral subicular-lesioned rats.
TLDR
The authors demonstrated the efficacy of enriched housing conditions in promoting the behavioral recovery and neuronal survival following subicular lesion in rats and implicates the effectiveness of activity-dependent neuronal plasticity induced by environmental enrichment in adulthood following brain insult.
Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice
Environmental enrichment and the sensory brain: the role of enrichment in remediating brain injury
TLDR
The role of EE in the treatment of experimental TBI is addressed, where the demonstrated sensorimotor and cognitive benefits associated with exposure to EE, and their possible mechanisms are discussed.
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References

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Involvement of Nerve Growth Factor in Visual Cortex Plasticity
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TLDR
Current evidence implies that NGF, and perhaps other neurotrophins as well, may be useful for preventing or correcting inappropriate or anomalous connections in the visual cortex, and thus for treating visual dysfunctions such as amblyopia and strabismus.
Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion
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TLDR
Results support the concept that NGF acts as trophic factor for magnocellular cholinergic neurons of the basal forebrain, and mRNANGF was found in the hippocampus and cortex but not in the septum.
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TLDR
It is demonstrated that exogenous NGF can cause significant compensatory changes in terminal fields and synaptic connections in the adult fully differentiated central nervous system.
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TLDR
It is concluded that the gene transfer procedure used here is efficient to provide the brain with a long-lasting local supply of exogenous NGF, induces long-term functional recovery of cognitive functions, and that independent trophic stimulation of the medial septum or nucleus basalis magnocellularis has similar consequences at the behavioral level.
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