Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins

@article{Nithianantharajah2004EnvironmentalER,
  title={Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins},
  author={Jess Nithianantharajah and Hannah Levis and Mark Murphy},
  journal={Neurobiology of Learning and Memory},
  year={2004},
  volume={81},
  pages={200-210}
}
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172 Citations
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172 Citations

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A single exposure to an enriched environment stimulates the activation of discrete neuronal populations in the brain of the fos-tau-lacZ mouse
ENHANCING PLASTICITY WITH FLUOXETINE AND ENRICHMENT IN THE ADULT RAT CORTEX
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The effects of fluoxetine, alone or in combination with monocular deprivation (MD), in the adult rat visual cortex is investigated and the impact of shortand long-term enrichment in theAdult rat somatomotor cortex is examined.
Motor Protein KIF1A Is Essential for Hippocampal Synaptogenesis and Learning Enhancement in an Enriched Environment
Sensorimotor Perturbation Induces Late and Transient Molecular Synaptic Proteins Activation and Expression Changes.
TLDR
It is concluded that experience-dependent reorganization of somatotopic cortical maps is accompanied by changes in synaptic transmission with a very close time-course.
Environmental Enrichment Repairs Structural and Functional Plasticity in the Hippocampus
TLDR
The hypothesis that the strict temporal organization of critical periods can be challenged by appropriate EE protocols, providing support for sustainable therapeutic interventions on neurological diseases characterized by permanent loss of function is explored.
The Effects of Enriched Environment on Structural Modification of Synaptic Interface and PSD-95 mRNA of Rats after Transient Focal Cerebral Ischemia
TLDR
The results suggest that the enriched environment significantly promoted spatial learning and memory in MCAO rats, and restrained the reduction of the synaptic density caused by cerebral ischemia,particularly in the frontal cortex.
MAP2 and synaptophysin protein expression following motor learning suggests dynamic regulation and distinct alterations coinciding with synaptogenesis
How Does an Enriched Environment Impact Hippocampus Brain Plasticity?
TLDR
The major role of the immune system is demonstrated in modulating EE-induced changes to hippocampal plasticity, which involves a variety of immune cells (including macrophages, microglia, natural killer, B-cells, and T-cells), although the mechanisms are yet to be fully elucidated.
An enriched environment restores normal behavior while providing cytoskeletal restoration and synaptic changes in the hippocampus of rats exposed to an experimental model of depression
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