Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins

@article{Nithianantharajah2004EnvironmentalER,
  title={Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins},
  author={Jess Nithianantharajah and Hannah Levis and Mark Murphy},
  journal={Neurobiology of Learning and Memory},
  year={2004},
  volume={81},
  pages={200-210}
}
ENHANCING PLASTICITY WITH FLUOXETINE AND ENRICHMENT IN THE ADULT RAT CORTEX
TLDR
The effects of fluoxetine, alone or in combination with monocular deprivation (MD), in the adult rat visual cortex is investigated and the impact of shortand long-term enrichment in theAdult rat somatomotor cortex is examined.
Sensorimotor Perturbation Induces Late and Transient Molecular Synaptic Proteins Activation and Expression Changes.
TLDR
It is concluded that experience-dependent reorganization of somatotopic cortical maps is accompanied by changes in synaptic transmission with a very close time-course.
Environmental Enrichment Repairs Structural and Functional Plasticity in the Hippocampus
TLDR
The hypothesis that the strict temporal organization of critical periods can be challenged by appropriate EE protocols, providing support for sustainable therapeutic interventions on neurological diseases characterized by permanent loss of function is explored.
The Effects of Enriched Environment on Structural Modification of Synaptic Interface and PSD-95 mRNA of Rats after Transient Focal Cerebral Ischemia
TLDR
The results suggest that the enriched environment significantly promoted spatial learning and memory in MCAO rats, and restrained the reduction of the synaptic density caused by cerebral ischemia,particularly in the frontal cortex.
How Does an Enriched Environment Impact Hippocampus Brain Plasticity?
TLDR
The major role of the immune system is demonstrated in modulating EE-induced changes to hippocampal plasticity, which involves a vari- ety of immune cells (including macrophages, microglia, natural killer, B-cells, and T-cells), although the mechanisms are yet to be fully elucidated.
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References

SHOWING 1-10 OF 66 REFERENCES
Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain
TLDR
Findings demonstrate significant alterations in NGF, BDNF, and NT-3 protein levels in several brain regions as a result of an enriched versus an isolated environment and thus provide a possible biochemical basis for behavioral and morphological alterations that have been found to occur with a shifting environmental stimulus.
Comparative evaluation of synaptophysin-based methods for quantification of synapses
TLDR
Stereology is the most useful method for estimating synaptic numbers in defined regions of the brain because it offers a high degree of anatomical resolution (lacking in Western blot methods) and has quantitative advantage over the greyscale-based density approach.
Neuronal Plasticity and Dendritic Spines: Effect of Environmental Enrichment on Intact and Postischemic Rat Brain
  • B. Johansson, P. Belichenko
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2002
TLDR
It is concluded that housing rats in an enriched environment significantly increases spine density in superficial cortical layers in intact and lesioned brain, but in deeper layers of intact brain.
PSD95 protein level rises in murine somatosensory cortex after sensory training
TLDR
Results indicate involvement of PSD95 in learning-dependent cortical plasticity in somatosensory cortex of mice.
In vivo activity-dependent plasticity at cortico-striatal connections: evidence for physiological long-term potentiation.
  • S. Charpier, J. Deniau
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
These findings demonstrate that LTP constitutes the normal form of use-dependent plasticity at cortico-striatal synapses and could be critical for the functions of basal ganglia in motor learning.
Altered synaptic transmission in dentate gyrus of rats reared in complex environments: evidence from hippocampal slices maintained in vitro.
TLDR
The results suggest that experience in a relatively complex environment is associated with greater MPP synaptic transmission arising from an increased synaptic input to granule cells and the experience-dependent synaptic alterations in the dentate gyrus are transient, in contrast to experience- dependent morphological alterations described in occipital cortex.
Mechanism for increased hippocampal synaptic strength following differential experience.
TLDR
The results suggest that baseline synaptic strength is determined, to a large extent, by presynaptic release mechanisms, however, increased synaptic transmission following environmental enrichment is likely due to an increase in the number or efficacy of receptors at some synapses and the emergence of functional synaptic contacts between previously unconnected CA3 and CA1 cells.
Bi-directional changes in synaptic plasticity induced at corticostriatal synapses in vitro
TLDR
It is reported here that tetanic stimulation of the white matter can readily induce long-term potentiation (LTP) at corticostriatal synapses in a sagittal slice preparation, and it is suggested that the corticOSTriatal depression reported here most likely involves the recruitment of local striatal circuits and dopaminergic inputs, and thus might explain the predominance of LTD previously reported.
...
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