Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.

@article{Morelli2014EnvironmentalER,
  title={Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.},
  author={Emanuela Morelli and Veronica Ghiglieri and Valentina Pendolino and Vincenza Bagetta and Annabella Pignataro and Anna Fejtova and C Costa and Martine Ammassari-Teule and Eckart D. Gundelfinger and Barbara Picconi and Paolo Calabresi},
  journal={Experimental neurology},
  year={2014},
  volume={261},
  pages={320-7}
}
We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented… CONTINUE READING

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