Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition

@article{Sale2007EnvironmentalEI,
  title={Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition},
  author={Alessandro Sale and José Fernando Maya Vetencourt and Paolo Medini and Maria Cristina Cenni and Laura Baroncelli and Roberto de Pasquale and Lamberto Maffei},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={679-681}
}
Loss of visual acuity caused by abnormal visual experience during development (amblyopia) is an untreatable pathology in adults. We report that environmental enrichment in adult amblyopic rats restored normal visual acuity and ocular dominance. These effects were due to reduced GABAergic inhibition in the visual cortex, accompanied by increased expression of BDNF and reduced density of extracellular-matrix perineuronal nets, and were prevented by enhancement of inhibition through benzodiazepine… 
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Amblyopia: background to the special issue on stroke recovery.
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Evidence from humans and animal models on the shaping of postnatal visual development by focused binocular input is summarized, finding ways to remediate vision in adulthood that bear some similarity to the interventions that have proved successful in promoting recovery from stroke.
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