Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice.

@article{Arranz2010EnvironmentalEI,
  title={Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice.},
  author={Lorena Arranz and Nuria M de Castro and Isabel Baeza and Ianire Mat{\'e} and Maria-Paz Viveros and M{\'o}nica De la Fuente},
  journal={Rejuvenation research},
  year={2010},
  volume={13 4},
  pages={
          415-28
        }
}
Age-related changes in immunity have been shown to highly influence morbidity and mortality. The aim of the present work was to study the effects of environmental enrichment (EE) (8-16 weeks) on several functions and oxidative stress parameters of peritoneal leukocytes, previously described as health and longevity markers, in mice at different ages, namely adult (44 +/- 4 weeks), old (69 +/- 4 weeks), and very old (92 +/- 4 weeks). Mortality rates were monitored in control and enriched animals… 

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References

SHOWING 1-10 OF 52 REFERENCES

An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice.

A Model of Premature Aging in Mice Based on Altered Stress-Related Behavioral Response and Immunosenescence

TLDR
Diet supplementation with antioxidants showed to be an effective strategy for protection against early immune and behavioral decline, altered redox state of leukocytes and premature mortality in PAM, which supports the validity of this model of premature aging as well as its link with oxidative stress.

Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing

Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity

TLDR
It is hypothesize that failures in innate immunity observed in frail elderly are related to those alterations described in adaptive immunity defined as the IRP, a predictor of mortality in elderly individuals that is based on several parameters of the adaptive immune response.

Environmental enrichment in mice decreases anxiety, attenuates stress responses and enhances natural killer cell activity

TLDR
EE has a beneficial effect on anxiety‐like behaviour, stress response andNK cell activity, and the effect on NK cell activity is promising, due to the role of NK cells in host resistance.

Environmental Enrichment‐Behavior‐Oxidative Stress Interactions in the Aged Rat: Issues for a Therapeutic Approach in Human Aging

TLDR
It is significant that neurotrophins, “novo” synthesis of neurotransmitters, and oxidative stress levels may mediate the observed changes, indicating that the aged brain still has appreciable plasticity in response to well‐manipulated environmental stimulation.

Clinical relevance of age-related immune dysfunction.

  • S. Castle
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2000
TLDR
This perspective will review clinically relevant infections in the elderly, focusing on influenza and influenza virus vaccination and how chronic illness contributes to increased risk and severity of infection and/or failed vaccine response.
...