Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice.

  title={Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice.},
  author={Lorena Arranz and Nuria M de Castro and Isabel Baeza and Ianire Mat{\'e} and Maria-Paz Viveros and M{\'o}nica De la Fuente},
  journal={Rejuvenation research},
  volume={13 4},
Age-related changes in immunity have been shown to highly influence morbidity and mortality. The aim of the present work was to study the effects of environmental enrichment (EE) (8-16 weeks) on several functions and oxidative stress parameters of peritoneal leukocytes, previously described as health and longevity markers, in mice at different ages, namely adult (44 +/- 4 weeks), old (69 +/- 4 weeks), and very old (92 +/- 4 weeks). Mortality rates were monitored in control and enriched animals… 

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This perspective will review clinically relevant infections in the elderly, focusing on influenza and influenza virus vaccination and how chronic illness contributes to increased risk and severity of infection and/or failed vaccine response.