Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity.

@article{Greifzu2014EnvironmentalEE,
  title={Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity.},
  author={Franziska Greifzu and Justyna Pielecka-Fortuna and Evgenia Kalogeraki and Katja Krempler and Plinio das N Favaro and Oliver M Schl{\"u}ter and Siegrid L{\"o}wel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 3},
  pages={1150-5}
}
Ocular dominance (OD) plasticity in mouse primary visual cortex (V1) declines during postnatal development and is absent beyond postnatal day 110 if mice are raised in standard cages (SCs). An enriched environment (EE) promotes OD plasticity in adult rats. Here, we explored cellular mechanisms of EE in mouse V1 and the therapeutic potential of EE to prevent impairments of plasticity after a cortical stroke. Using in vivo optical imaging, we observed that monocular deprivation in adult EE mice… CONTINUE READING
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