Environmental enrichment enhances neurogranin expression and hippocampal learning and memory but fails to rescue the impairments of neurogranin null mutant mice.

Abstract

Environmental enrichment is known to enhance hippocampal neurogenesis and cognitive functions. Neurogranin (Ng), a specific substrate of protein kinase C (PKC), is abundantly expressed in brain regions important for cognitive functions. Deletion of Ng in mice causes severe deficits in spatial learning and long-term potentiation (LTP) in the hippocampal CA1… (More)

Topics

5 Figures and Tables

Cite this paper

@article{Huang2006EnvironmentalEE, title={Environmental enrichment enhances neurogranin expression and hippocampal learning and memory but fails to rescue the impairments of neurogranin null mutant mice.}, author={Freesia L. Huang and Kuo-ping Huang and Junfang Wu and Catherine Boucheron}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2006}, volume={26 23}, pages={6230-7} }