Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome –Mecp2 gene dosage effects and BDNF expression

@article{Kondo2008EnvironmentalEA,
  title={Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome –Mecp2 gene dosage effects and BDNF expression},
  author={Mari A. Kondo and Laura Gray and Gregory J. Pelka and John Christodoulou and Patrick P. L. Tam and Anthony John Hannan},
  journal={European Journal of Neuroscience},
  year={2008},
  volume={27}
}
Rett syndrome, commonly associated with mutations of the methyl CpG‐binding protein 2 (MECP2) gene, is characterised by an apparently normal early postnatal development followed by deterioration of acquired cognitive and motor coordination skills in early childhood. To evaluate whether environmental factors may influence the disease outcome of Rett syndrome, we tested the effect of environmental enrichment from 4 weeks of age on the behavioural competence of mutant mice harboring a Mecp2 tm1Tam… 
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