Environmental co-factors in HPV carcinogenesis.

@article{Castellsagu2002EnvironmentalCI,
  title={Environmental co-factors in HPV carcinogenesis.},
  author={Xavier Castellsagu{\'e} and Francesc Xavier Bosch and Nubia Mu{\~n}oz},
  journal={Virus research},
  year={2002},
  volume={89 2},
  pages={
          191-9
        }
}
Epidemiological studies have shown that only a small fraction of women infected with oncogenic HPV types will eventually progress to high-grade intraepithelial lesions (HSIL) and cervical cancer (CC). Because infection by oncogenic HPVs is a necessary but not a sufficient cause of CC, it has been assumed that other factors, acting in conjunction with HPV, influence the risk of transition from cervical HPV infection to cervical malignancy. This paper reviews the epidemiological evidence for the… CONTINUE READING

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