Environmental chemicals impacting the thyroid: targets and consequences.

  title={Environmental chemicals impacting the thyroid: targets and consequences.},
  author={R. Zoeller},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={17 9},
  • R. Zoeller
  • Published 2007
  • Biology, Medicine
  • Thyroid : official journal of the American Thyroid Association
  • Thyroid hormone (TH) is essential for normal brain development, but the specific actions of TH differ across developmental time and brain region. These actions of TH are mediated largely by a combination of thyroid hormone receptor (TR) isoforms that exhibit specific temporal and spatial patterns of expression during animal and human brain development. In addition, TR action is influenced by different cofactors, proteins that directly link the TR protein to functional changes in gene expression… CONTINUE READING
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