Environmental cadmium exposure and osteoporosis: a review

@article{James2013EnvironmentalCE,
  title={Environmental cadmium exposure and osteoporosis: a review},
  author={Katherine A. James and Jaymie R. Meliker},
  journal={International Journal of Public Health},
  year={2013},
  volume={58},
  pages={737-745}
}
ObjectivesTo review the published literature investigating the association between cadmium exposure and osteoporosis.MethodsA review of published peer-reviewed literature based on a priori criteria was completed. Odds ratios (OR) were abstracted or estimated from observational studies to calculate a pooled OR using inverse variance weighted random effects models.ResultsThe review identified seven studies with a pooled OR of OR = 2.22 (95 % CI: 1.16, 4.28) [I2 = 54.8 % (p < 0.05)] (comparing… Expand
Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis
TLDR
This meta-analysis suggests that high U-Cd/B-cd exposure may not be risk factor for DM in general populations, however, large prospective studies are needed to confirm this finding. Expand
Urinary cadmium and mortality from all causes, cancer and cardiovascular disease in the general population: systematic review and meta-analysis of cohort studies.
TLDR
Even at low-level exposure, cadmium appears to be associated with increased mortality at all causes, cancer and cardiovascular disease in the general population. Expand
Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries: France, Spain and Belgium.
TLDR
The results support the importance of reducing exposure of the general population to Cd, and stand for a major contributing role of Cd exposure in the overall social costs related to osteoporosis. Expand
Increased blood cadmium levels were not associated with increased fracture risk but with increased total mortality in women: the Malmö Diet and Cancer Study
TLDR
Higher blood levels of cadmium did not increase fracture risk in middle-aged women but reduced overall survival, and the risk of fracture was not associated with baseline B-Cd in adjusted models. Expand
Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data.
TLDR
The findings, through direct bone analyses, support the emerging epidemiological view that bone health, adjudged by mineral density, is extremely sensitive to even background levels of environmental Cd and suggest that Cd may play an even greater role in compromised bone health than prior indirect estimates of exposure could reveal. Expand
Cadmium Exposure is Associated with the Prevalence of Dyslipidemia
TLDR
Elevated blood cadmium concentration is associated with prevalence of dyslipidemia and the profile of blood lipid was obviously changed in this occupational population of workers occupationally exposed to Cadmium in China. Expand
Low‐Level Cadmium Exposure Is Associated With Decreased Bone Mineral Density and Increased Risk of Incident Fractures in Elderly Men: The MrOS Sweden Study
TLDR
The results indicate that even relatively low cadmium exposure through diet and smoking increases the risk of low BMD and osteoporosis‐related fractures in elderly men. Expand
Smoking‐Induced Risk of Osteoporosis Is Partly Mediated by Cadmium From Tobacco Smoke: The MrOS Sweden Study
  • Huiqi Li, Maria Wallin, +5 authors E. Andersson
  • Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2020
TLDR
Evidence is provided that cadmium exposure from tobacco smoke plays an important role in smoking‐induced osteoporosis, and this study was performed in a Swedish cohort of elderly men from the Osteoporotic Fractures in Men study. Expand
Risk assessment of effects of cadmium on human health (IUPAC Technical Report)
Abstract Chemistry and Human Health, Division VII of the International Union on Pure and Applied Chemistry (IUPAC), provides guidance on risk assessment methodology and, as appropriate, assessment ofExpand
Investigation of the relationship between low environmental exposure to metals and bone mineral density, bone resorption and renal function.
TLDR
Urinary cadmium was found to be a significant predictor of bone mineral density at whole body, lumber spine, total hip and femoral neck, with increasing urinary Cd concentrations associated with decreased bone density. Expand
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Cadmium may be a risk factor for the development of osteoporosis at lower doses than previously anticipated, and there was a suggested dose-effect relation between cadmium dose and bone mineral density. Expand
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TLDR
Exposure to low levels of cadmium is associated with an increased risk of osteoporosis, particularly apparent in persons over 60 years of age. Expand
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TLDR
Results suggested that U-Cd might be associated with osteopenia as well as osteoporosis in both male and female adults. Expand
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