Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.

@article{Lichtenstein2000EnvironmentalAH,
  title={Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.},
  author={Paul Lichtenstein and Niels Vilstrup Holm and Pia K. Verkasalo and Aliki Iliadou and Jaakko Kaprio and Markku Koskenvuo and Eero I Pukkala and Axel E Skytthe and Kari Hemminki},
  journal={The New England journal of medicine},
  year={2000},
  volume={343 2},
  pages={78-85}
}
BACKGROUND The contribution of hereditary factors to the causation of sporadic cancer is unclear. Studies of twins make it possible to estimate the overall contribution of inherited genes to the development of malignant diseases. METHODS We combined data on 44,788 pairs of twins listed in the Swedish, Danish, and Finnish twin registries in order to assess the risks of cancer at 28 anatomical sites for the twins of persons with cancer. Statistical modeling was used to estimate the relative… CONTINUE READING
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