Environmental and genetic risk factors and gene-environment interactions in the pathogenesis of chronic obstructive lung disease.

@article{Walter2000EnvironmentalAG,
  title={Environmental and genetic risk factors and gene-environment interactions in the pathogenesis of chronic obstructive lung disease.},
  author={R. Walter and D. Gottlieb and G. O'Connor},
  journal={Environmental Health Perspectives},
  year={2000},
  volume={108},
  pages={733 - 742}
}
Current understanding of the pathogenesis of chronic obstructive pulmonary disease (COPD), a source of substantial morbidity and mortality in the United States, suggests that chronic inflammation leads to the airways obstruction and parenchymal destruction that characterize this condition. Environmental factors, especially tobacco smoke exposure, are known to accelerate longitudinal decline of lung function, and there is substantial evidence that upregulation of inflammatory pathways plays a… Expand
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