Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

  title={Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.},
  author={Anna Villar-Piqu{\'e} and Tom{\'a}s Lopes da Fonseca and Ricardo Luis Sant'Anna and {\'E}va M{\'o}nika Szeg{\"o} and Luis Fonseca-Ornelas and Raquel Meneses Ricardo Coutinho Jose Carlos Pinho and Anita Carija and Ellen Gerhardt and Caterina Masaracchia and Enrique Abad Gonzalez and Giulia Rossetti and Paolo Carloni and Claudio O Fern{\'a}ndez and Debora Foguel and Ira Milosevic and Markus Zweckstetter and Salvador Ventura and Tiago F Outeiro},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 42},
Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant neuronal protein that can adopt different conformations and biological properties. Recently, aSyn pathology was shown to spread between neurons in a prion-like manner. Proteins like aSyn that exhibit self-propagating capacity appear to be able to adopt different stable conformational states, known as protein strains, which can be modulated both by… CONTINUE READING
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