Environmental Stresses Disrupt Telomere Length Homeostasis

Abstract

Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease. Recent studies have additionally found a correlation between psychological stress, telomere length, and health outcome in humans. However, studies have not yet explored the causal relationship between stress and telomere length, or the molecular mechanisms underlying that relationship. Using yeast as a model organism, we show that stresses may have very different outcomes: alcohol and acetic acid elongate telomeres, whereas caffeine and high temperatures shorten telomeres. Additional treatments, such as oxidative stress, show no effect. By combining genome-wide expression measurements with a systematic genetic screen, we identify the Rap1/Rif1 pathway as the central mediator of the telomeric response to environmental signals. These results demonstrate that telomere length can be manipulated, and that a carefully regulated homeostasis may become markedly deregulated in opposing directions in response to different environmental cues.

DOI: 10.1371/journal.pgen.1003721

Extracted Key Phrases

4 Figures and Tables

0502014201520162017
Citations per Year

92 Citations

Semantic Scholar estimates that this publication has 92 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@inproceedings{Romano2013EnvironmentalSD, title={Environmental Stresses Disrupt Telomere Length Homeostasis}, author={Gal Hagit Romano and Yaniv Harari and Tal Yehuda and Ariel Podhorzer and Linda Rubinstein and Ron Shamir and Assaf Gottlieb and Yael Silberberg and Dana Pe'er and Eytan Ruppin and Roded Sharan and Martin Kupiec}, booktitle={PLoS genetics}, year={2013} }