Environmental Stress Affects DNA Methylation of a CpG Rich Promoter Region of Serotonin Transporter Gene in a Nurse Cohort

@inproceedings{Alasaari2012EnvironmentalSA,
  title={Environmental Stress Affects DNA Methylation of a CpG Rich Promoter Region of Serotonin Transporter Gene in a Nurse Cohort},
  author={Jukka S. Alasaari and Markus Lagus and Hanna Maria Ollila and Auli Toivola and Mika Kivim{\"a}ki and Jussi Vahtera and Erkki Kronholm and Mikko H{\"a}rm{\"a} and Sampsa Puttonen and Tiina Paunio},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Shift-working nurses are exposed to a stressful work environment, which puts them at an increased risk for burnout and depression. We explored the effect of environmental stress on serotonin transporter gene (SLC6A4) promoter methylation among nurses from high and low work stress environments. METHODOLOGY Using bisulfite sequencing, we investigated the methylation status of five CpG residues of a CpG-rich region in the promoter of SLC6A4 by comparing female shift working nurses… CONTINUE READING
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