Environmental Sensory Signals and Microbial Pathogenesis: Pseudomonas aeruginosa Infection in Cystic Fibrosis

@article{DeVault1989EnvironmentalSS,
  title={Environmental Sensory Signals and Microbial Pathogenesis: Pseudomonas aeruginosa Infection in Cystic Fibrosis},
  author={James D. DeVault and Alan Berry and Tapan K. Misra and Aldis Darzins and Ananda M. Chakrabarty},
  journal={Bio/Technology},
  year={1989},
  volume={7},
  pages={352-357}
}
Pseudomonas aeruginosa produces the exo–polysaccharide alginate almost exclusively in association with pulmonary infection in cystic fibrosis (CF). Transcriptional activation of the P. aeruginosa alginate genes appears to be affected by the growth environment. Two regulatory genes have been implicated in this environmental activation, one of which produces a gene product having significant amino acid homology with a class of regulatory proteins responsive to environmental stimuli. Understanding… CONTINUE READING

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