Environmental Exposure to Allergens of Different Dog Breeds and Relevance in Allergological Diagnostics

@article{Heutelbeck2008EnvironmentalET,
  title={Environmental Exposure to Allergens of Different Dog Breeds and Relevance in Allergological Diagnostics},
  author={Astrid Rita Regina Heutelbeck and Thomas G. Schulz and Karl‐Christian Bergmann and Ernst Hallier},
  journal={Journal of Toxicology and Environmental Health, Part A},
  year={2008},
  volume={71},
  pages={751 - 758}
}
In our environment, dogs are a relevant source of allergens, but diagnosing dog-related allergies may present difficulties, as in diagnostic tests with commercial dog allergens, some patients show only slight positive or negative results, even though they suffer from dog-related symptoms. Occasionally, allergy tests with extracts of dog hair belonging to patients' dogs or from dogs of the same breed were found to yield more reliable results, possibly due to breed-specific allergen components… Expand
Exposure to allergens of different cattle breeds and their relevance in occupational allergy
TLDR
The results of this study strongly support the following recommendation: test results with commercial extracts that are contradictory to the clinical symptoms should be supplemented by skin tests using extracts of the hair of the farmers’ own cattle. Expand
Skin Prick Test Extracts for Dog Allergy Diagnosis Show Considerable Variations Regarding the Content of Major and Minor Dog Allergens
TLDR
The observed variability of commercial dog SPT extracts regarding their allergen contents likely has a negative influence on the accuracy of diagnosis of dog allergy. Expand
The NPC2 protein: A novel dog allergen.
TLDR
NPC2 protein, a member of the MD-2-related lipid recognition family, is identified as a dog allergen, with an apparent seroprevalence of 10% to 20%. Expand
Development of a Sandwich ELISA to Measure Exposure to Occupational Cow Hair Allergens
TLDR
The ELISA developed for the detection of cow hair proteins is a useful tool for allergen quantification in occupational and home environments based on its low detection limit, which is sensitive enough to detect allergens in passive airborne dust. Expand
Dog allergen levels in homes with hypoallergenic compared with nonhypoallergenic dogs
TLDR
No classification scheme showed that the level of dog allergen in homes with hypoallergenic dogs differed from other homes, and dog-allergic individuals should have access to scientifically valid information on thelevel of allergenic shedding of different breeds of dogs. Expand
Dog and Cat Allergies: Current State of Diagnostic Approaches and Challenges
TLDR
The ability to diagnose cat sensitization is good, in contrast to dogs, and component resolved diagnostics of sensitization to individual allergenic proteins will dramatically improve diagnosis. Expand
Do hypoallergenic cats and dogs exist?
  • A. Butt, Daanish Rashid, R. Lockey
  • Medicine
  • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2012
TLDR
The notion that a particular cat or dog breed is “hypoallergenic” has the potential to be a lucrative business and many misconceptions persist among physicians, health care professionals, and the general population about pet dander allergy. Expand
Molecular approaches for characterization, diagnosis and therapy of allergy to pets
TLDR
To improve diagnostics by characterizing extracts and evaluating component based microarrays to conventional methods, to identify new allergens as well as describe previously only partially characterized allergens, their distribution and properties are described. Expand
Immunological methods for diagnosis and monitoring of IgE‐mediated allergy caused by industrial sensitizing agents (IMExAllergy)
TLDR
Major recommendations based on the presented data include diagnostic use of sIgE to HMW allergens, and the requirements for full transparency of the content of allergen preparations with details on standardization and quality control are underlined. Expand
Can f 1 levels in hair and homes of different dog breeds: lack of evidence to describe any dog breed as hypoallergenic.
TLDR
So-called hypoallergenic dogs had higher Can f 1 levels in hair and coat samples than did control breeds, but these differences did not lead to higher levels of environmental exposure to dog allergens. Expand
...
1
2
...

References

SHOWING 1-10 OF 29 REFERENCES
Breed-specific dog-dandruff allergens.
Fifty-one patients with clinical history of dog allergy were skin prick tested with eight individual standardized dog breed-allergen preparations, one mixed breed-allergen preparationExpand
Dog dander allergens. Specificity studies based on the radioallergosorbent technique.
  • R. Brandt, L. Yman
  • Medicine
  • International archives of allergy and applied immunology
  • 1980
TLDR
The dog dander is the preferable source of dog epithelium allergens provided that the existence of relations to other animals is considered. Expand
Characterisation of dog allergens by means of immunoblotting.
TLDR
Sera from 75 patients with clinical type I allergy against dogs were investigated by means of immunoblotting using extracts prepared from dog hair/dander and saliva, and it was concluded that the 23-kD protein is preferentially expressed in hair and saliva whereas the 19-kd protein is found in saliva and skin. Expand
Assay for the major dog allergen, Can f I: investigation of house dust samples and commercial dog extracts.
TLDR
This Can f I assay demonstrated no reaction with 17 heterologous allergen sources, including dog albumin, cat, guinea pig, and horse, and will provide useful information for assessing commercial extracts as well as monitoring dog-allergen exposure andAllergen-control methods. Expand
Allergenicity and cross‐reactivity of cat and dog allergenic extracts
TLDR
It is confirmed that cat allergen 1 (CAT‐1) is a major allergenic determinant in cat‐sensitive patients, and the role of other determinants is defined, as well as the determinants responsible for the cross‐reactivity between cat and dog extracts. Expand
Purification and characterization of the major dog allergen, Can f I
TLDR
An important dog‐hair and dander‐specific allergen Ag13 has been purified by means of immunoaffinity chromatography utilizing rabbit antibody specific for Ag13, and it is suggested that Ag13 be termed Can f I. Expand
Breed-specific dog hypersensitivity in humans.
  • B. Moore, J. Hyde
  • Medicine
  • The Journal of allergy and clinical immunology
  • 1980
TLDR
Variability of skin test and RAST responses to different dog breed dander extracts support the existence of breed-specific allergens. Expand
Allergen profiles of dog hair and dander, body fluids and tissues as defined by immunoblotting.
TLDR
Inhibition experiments using the 23-kDa containing extract prepared from hair and the 19-k Da containing Extract prepared from skin revealed that these two proteins are likely to be immunologically independent allergens. Expand
Skin prick test in the diagnosis of dog dander allergy A comparison of different extracts with clinical history, provocation tests and RAST
TLDR
The overall agreement between the SPT reactions to the different allergens was good, however, significant differences were observed in the allergenic activity of the different preparations and between different batches from the same manufacturer. Expand
Identification of allergens in dog dander extract. I. Clinical and immunological aspects of allergenicity activity.
TLDR
Allergenic activity of mixed dog dander extract was compared with dog serum albumin by skin testing, RAST testing and RAST inhibition, finding additional lower molecular weight allergens determined by sucrose density gradient centrifugation and immunoelectrophoresis. Expand
...
1
2
3
...