Environmental Enteric Dysfunction is Associated with Carnitine Deficiency and Altered Fatty Acid Oxidation

@inproceedings{Semba2017EnvironmentalED,
  title={Environmental Enteric Dysfunction is Associated with Carnitine Deficiency and Altered Fatty Acid Oxidation},
  author={Richard D. Semba and Indi Trehan and Ximin Li and Ruin Moaddel and Maria Isabel Ordiz and Kenneth M Maleta and Klaus Kraemer and Michelle D Shardell and Luigi Ferrucci and Mark J. Manary},
  booktitle={EBioMedicine},
  year={2017}
}
BACKGROUND Environmental enteric dysfunction (EED), a condition characterized by small intestine inflammation and abnormal gut permeability, is widespread in children in developing countries and a major cause of growth failure. The pathophysiology of EED remains poorly understood. METHODS We measured serum metabolites using liquid chromatography-tandem mass spectrometry in 400 children, aged 12-59months, from rural Malawi. Gut permeability was assessed by the dual-sugar absorption test… CONTINUE READING
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