Environmental Enrichment Induces Synaptic Structural Modification After Transient Focal Cerebral Ischemia in Rats

  title={Environmental Enrichment Induces Synaptic Structural Modification After Transient Focal Cerebral Ischemia in Rats},
  author={Xiaohong Xu and Lingjing Ye and Qin Ruan},
  journal={Experimental Biology and Medicine},
  pages={296 - 305}
Environmental enrichment (EE), where animals are exposed to a complex novel environment, has been shown to induce synaptic plasticity in both intact and injured animals. The purpose of this study was to investigate the effects of EE on spatial memory and structural modifications of synaptic junctions in rats following transient focal cerebral ischemia. Adult male Sprague-Dawley rats underwent right middle cerebral artery occlusion (MCAO) for 40 min and reperfusion. On day 3 after MCAO or sham… 

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Neuronal Plasticity and Dendritic Spines: Effect of Environmental Enrichment on Intact and Postischemic Rat Brain
  • B. Johansson, P. Belichenko
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2002
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